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HU Xueyi, LI Xiaoming, MENG Linghong, WANG Bingui. Antioxidant bisabolane-type sesquiterpenoids from algalderived fungus Aspergillus sydowii EN-434[J]. Journal of Oceanology and Limnology, 2020, 38(5): 1532-1536 |
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Antioxidant bisabolane-type sesquiterpenoids from algalderived fungus Aspergillus sydowii EN-434 |
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| HU Xueyi1,2, LI Xiaoming1,3, MENG Linghong1,3, WANG Bingui1,3 |
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1 Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, and Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, China;
2 College of Earth Science, University of Chinese Academy of Sciences, Beijing 100049, China;
3 Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao 266071, China |
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| Abstract: |
| A new aromatic bisabolene-type sesquiterpenoid (7S,8S)-8-hydroxysydowic acid (1), together with a pair of new bisabolene derivative (±)-(7R*,10R*)-10-hydroxysydowic acid (2), as well as two known analogues hydroxysydonic acid (3) and sydowic acid (4) were isolated and identified from the endophytic fungal strain Aspergillus sydowii EN-434 that was obtained from the marine red alga Symphyocladia latiuscula. Their structures were elucidated by nuclear magnetic resonance (NMR), high resolution electrospray ionization mass spectroscopy (HRESIMS), and quantum chemical electronic circular dichroism (ECD) calculations as well as comparison of the data with literature reports. Compound 1 exhibited potent DPPH free radical scavenging activity with IC50 value of 113.5 μmol/L. |
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| Key words:
Aspergillus sydowii|algal-derived fungus|bisabolene-type sesquiterpenoid|antioxidant activity
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| Received: 2020-01-23 Revised: 2020-04-03 |
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