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Cite this paper: |
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CHANG Zhiqiang, LIU Fei, LIAN Chun'ang, ZHAI Qianqian, LI Jian. Pharmacokinetics and acetylation of sulfamethoxazole in turbot Scophthalmus maximus after intravascular administration[J]. Journal of Oceanology and Limnology, 2016, 34(4): 789-794 |
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Pharmacokinetics and acetylation of sulfamethoxazole in turbot Scophthalmus maximus after intravascular administration |
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CHANG Zhiqiang1, LIU Fei1,2, LIAN Chun'ang1,2, ZHAI Qianqian1, LI Jian1 |
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1 Key Laboratory of Sustainable Development of Marine Fisheries, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China; 2 College of Fisheries and Life Sciences, Shanghai Ocean University, Shanghai 201306, China |
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Abstract: |
The pharmacokinetic profiles and sulfamethoxazole (SMX) acetylation process in turbot reared at 18℃ were investigated. Either SMX (parent drug) or its acetylized metabolite, N 4-acetylsulfamethoxazole (AcSMX), was administered intravascularly to turbot at a dosage of 50 mg/kg BW. Serum concentrations of the parent drug and its metabolite were both measured by HPLC, and the changes in concentration over time were analyzed in two-and non-compartment models because SMX treatment produced multiple peaks. The results demonstrated that the elimination half-life of the parent drugs, SMX and AcSMX, were 159.2 and 5.9 h, respectively. The apparent volume of distribution was 0.2 and 0.8 L/kg, and the clearance was 0.038 and 0.222 L/(h·kg), for SMX and AcSMX, respectively. SMX acetylation in turbot was 2.8%, and the deacetylation of AcSMX was 0.2%. These findings may be useful in optimizing SMX dosage regimens in turbot aquaculture. |
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Key words:
pharmacokinetics|acetylation|sulfamethoxazole|turbot
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Received: 2014-12-30 Revised: 2015-02-25 |
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