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YANG Haibin, LI Fang, JI Naiyun. Alkaloids from an algicolous strain of Talaromyces sp.[J]. Journal of Oceanology and Limnology, 2016, 34(2): 367-371

Alkaloids from an algicolous strain of Talaromyces sp.

YANG Haibin1,2, LI Fang1, JI Naiyun2
1 College of Chemistry and Molecular Engineering, Qingdao University of Science & Technology, Qingdao 266042, China;
2 Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China
Compounds isolated and identifi ed in a culture of the alga-endophytic fungus Talaromyces sp. cf-16 included two naturally occurring alkaloids, 2-[(S)-hydroxy(phenyl)methyl]-3-methylquinazolin-4(3H)-one(1a) and 2-[(R)-hydroxy(phenyl)methyl]-3-methylquinazolin-4(3H)-one(1b), that were identified for the first time. In addition, seven known compounds(2-8) were obtained from the culture. Following chiral column chromatography, compounds 1a and 1b were identified as enantiomers by spectroscopic analyses and quantum chemical calculations. Bioassay results showed that 5 was more toxic to brine shrimp than the other compounds, and that 3-6 could inhibit Staphylococcus aureus.
Key words:    Talaromyces sp.|alkaloid|chiral separation|quantum chemical calculation|bioactivity   
Received: 2014-12-25   Revised: 2015-03-26
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