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ZHANG Hongyu, XIE Zeping, LOU Tingting, JIANG Peng. Isolation, identifi cation, and cytotoxicity of a new isobenzofuran derivative from marine Streptomyces sp. W007[J]. Journal of Oceanology and Limnology, 2016, 34(2): 386-390

Isolation, identifi cation, and cytotoxicity of a new isobenzofuran derivative from marine Streptomyces sp. W007

ZHANG Hongyu1, XIE Zeping3, LOU Tingting4, JIANG Peng2
1 Tianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China;
2 Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China;
3 School of Pharmacy, Binzhou Medical University, Yantai 264003, China;
4 Tianjin Entry & Exit Inspection and Quarantine Bureau, Tianjin 300461, China
A new isobenzofuran derivative(1) was isolated from the marine Streptomyces sp. W007 and its structure was determined through extensive spectroscopic analyses, including 1D-NMR, 2D-NMR, and ESI-MS. The absolute configuration of compound 1 was determined by a combination of experimental analyses and comparison with reported data, including biogenetic reasoning, J-coupling analysis, NOESY, and 1H-1HCOSY. Compound 1 exhibited no cytotoxicity against human cells of gastric cancer BGC-823, lung cancer A549, and breast cancer MCF7.
Key words:    marine streptomycete|isobenzofuran derivative|absolute confi guration|cytotoxicity   
Received: 2014-11-19   Revised: 2015-01-30
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