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XIA Dong, LIU Bing, LUAN Xiying, SUN Junyan, LIU Nana, QIN Song, DU Zhenning. Protective eff ects of C-phycocyanin on alcohol-induced acute liver injury in mice[J]. Journal of Oceanology and Limnology, 2016, 34(2): 399-404

Protective eff ects of C-phycocyanin on alcohol-induced acute liver injury in mice

XIA Dong1, LIU Bing2, LUAN Xiying3, SUN Junyan2, LIU Nana2, QIN Song2, DU Zhenning1
1 School of Pharmacy, Yantai University, Yantai 264005, China;
2 Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China;
3 School of Basic Medical, Binzhou Medical University, Yantai 264003, China
Excessive alcohol consumption leads to liver disease. Extensive evidence suggests that C-phycocyanin(C-PC), a chromophore phycocyanobilin derived from Spirulina platensis, exerts protective effects against chemical-induced organ damage. In this study, we investigated whether C-PC could protect against ethanol-induced acute liver injury. Serum alanine aminotransferase(ALT), aspartate aminotransferase(AST), triglyceride(TG), total cholesterol(CHOL), low-density lipoprotein(LDL), liver homogenate malondialdehyde(MDA), superoxide dismutase(SOD) content were measured, and pathological examination of liver sections were examined. C-PC showed obvious inhibitory effects on serum ALT, AST, TG, CHOL, LDL and MDA, and SOD content significantly increased in the liver. The structure of hepatic lobules was clear, liver sinus returned to normal, and liver cell cords were arranged in neat rows. Cloudiness, swelling, inflammatory cell infiltration and spotty necrosis of liver cells were significantly reduced. Therefore, C-PC can significantly protect against ethanol-induced acute liver injury.
Key words:    C-phycocyanin|acute ethanol liver injury|protective eff ect   
Received: 2014-11-24   Revised: 2015-02-25
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