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Cite this paper: |
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LI Peihai, FAN Yaqin, CHEN Hao, CHAO Yaxi, DU Ning, CHEN Junhui. Phenylquinolinones with antitumor activity from the Indian Ocean-derived fungus Aspergillus versicolor Y31-2[J]. Journal of Oceanology and Limnology, 2016, 34(5): 1072-1075 |
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Phenylquinolinones with antitumor activity from the Indian Ocean-derived fungus Aspergillus versicolor Y31-2 |
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| LI Peihai, FAN Yaqin, CHEN Hao, CHAO Yaxi, DU Ning, CHEN Junhui |
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| Key Lab of Marine Bioactive Substances, First Institute of Oceanography, State Oceanic Administration(SOA), Qingdao 266000, China |
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| Abstract: |
| Two phenylquinolinones, including one new compound (1) and a previously isolated compound (2), were isolated from the ethyl acetate extracts of the fungus Aspergillus versicolor Y31-2, which was obtained from seawater samples collected from the Indian Ocean. The structures of these compounds were established by spectroscopic analyses. 4-(3-Hydroxyphenyl)-3-methoxyquinolin-2(1H)-one (1) exhibited moderate cytotoxicity against MCF-7 (human breast carcinoma cell line) and SMMC-7721 (human liver cancer cell line) cells with IC50 values of 16.6 and 18.2 μmol/L, respectively. To the best of our knowledge, this study represents the first reported account of the isolation of compounds 1 and 2 as the secondary metabolites of the seawater derived fungus Aspergillus versicolor from the Indian Ocean. |
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| Key words:
phenylquinolinones|anti-tumor|Aspergillus versicolor
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| Received: 2015-03-30 Revised: 2015-06-08 |
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