Cite this paper:
YU Weiting, ZHANG Demeng, LIU Xiudong, WANG Yunhong, TONG Jun, ZHANG Mengxue, MA Xiaojun. Amphiphilic sodium alginate-vinyl acetate microparticles for drug delivery[J]. HaiyangYuHuZhao, 2019, 37(3): 855-862

Amphiphilic sodium alginate-vinyl acetate microparticles for drug delivery

YU Weiting1, ZHANG Demeng2,4, LIU Xiudong3, WANG Yunhong3, TONG Jun3, ZHANG Mengxue4, MA Xiaojun5
1 Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China;
2 Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China;
3 College of Environment and Chemical Engineering, Dalian University, Dalian Economic Technological Development Zone, Dalian 116622, China;
4 State Key Laboratory of Bioactive Seaweed Substances, Qingdao Brightmoon Seaweed Group Co. Ltd., Qingdao 266400, China;
5 Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
To overcome the fast or burst release of hydrophilic drugs from hydrophilic alginate-based carriers, hydrophobic molecule (vinyl acetate, VAc) was grafted on alginate (Alg), which was further used to prepare drug carriers. Amphiphilic Alg-g-PVAc hydrogel beads were firstly prepared by emulsification/internal gelation technique for the loading of bovine serum albumin (BSA). Then, chitosan was coated on the surface of beads to form novel amphiphilic Alg-g-PVAc/chitosan (Alg-g-PVAc/CS) microcapsules. The BSA-loading amphiphilic Alg-g-PVAc/chitosan (Alg-g-PVAc/CS) microcapsules display similar morphology and size to the hydrophilic alginate/chitosan (AC) microcapsules. However, the drug loading and loading efficiency of BSA in Alg-g-PVAc/CS microcapsules are higher, and the release rate of BSA from Alg-g-PVAc/CS microcapsules is slower. The results demonstrate that the introduction of hydrophobic PVAc on alginate can effectively help retard the release of BSA, and the higher degree of substitution is, the slower the release rate is. In addition, the complex membrane can also be adjusted to delay the release of BSA. As a whole, amphiphilic sodium alginate-vinyl acetate/CS microparticles could be developed for macromolecular drug delivery.
Key words:    hydrophobic modification|sodium alginate-vinyl acetate|amphiphilic Alg-g-PVAc/chitosan microcapsules|drug delivery   
Received: 2018-05-09   Revised: 2018-06-20
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