Cite this paper:
YU Weiting, ZHANG Demeng, LIU Xiudong, WANG Yunhong, TONG Jun, ZHANG Mengxue, MA Xiaojun. Amphiphilic sodium alginate-vinyl acetate microparticles for drug delivery[J]. HaiyangYuHuZhao, 2019, 37(3): 855-862

Amphiphilic sodium alginate-vinyl acetate microparticles for drug delivery

YU Weiting1, ZHANG Demeng2,4, LIU Xiudong3, WANG Yunhong3, TONG Jun3, ZHANG Mengxue4, MA Xiaojun5
1 Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China;
2 Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China;
3 College of Environment and Chemical Engineering, Dalian University, Dalian Economic Technological Development Zone, Dalian 116622, China;
4 State Key Laboratory of Bioactive Seaweed Substances, Qingdao Brightmoon Seaweed Group Co. Ltd., Qingdao 266400, China;
5 Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
Abstract:
To overcome the fast or burst release of hydrophilic drugs from hydrophilic alginate-based carriers, hydrophobic molecule (vinyl acetate, VAc) was grafted on alginate (Alg), which was further used to prepare drug carriers. Amphiphilic Alg-g-PVAc hydrogel beads were firstly prepared by emulsification/internal gelation technique for the loading of bovine serum albumin (BSA). Then, chitosan was coated on the surface of beads to form novel amphiphilic Alg-g-PVAc/chitosan (Alg-g-PVAc/CS) microcapsules. The BSA-loading amphiphilic Alg-g-PVAc/chitosan (Alg-g-PVAc/CS) microcapsules display similar morphology and size to the hydrophilic alginate/chitosan (AC) microcapsules. However, the drug loading and loading efficiency of BSA in Alg-g-PVAc/CS microcapsules are higher, and the release rate of BSA from Alg-g-PVAc/CS microcapsules is slower. The results demonstrate that the introduction of hydrophobic PVAc on alginate can effectively help retard the release of BSA, and the higher degree of substitution is, the slower the release rate is. In addition, the complex membrane can also be adjusted to delay the release of BSA. As a whole, amphiphilic sodium alginate-vinyl acetate/CS microparticles could be developed for macromolecular drug delivery.
Key words:    hydrophobic modification|sodium alginate-vinyl acetate|amphiphilic Alg-g-PVAc/chitosan microcapsules|drug delivery   
Received: 2018-05-09   Revised: 2018-06-20
Tools
PDF (711 KB) Free
Print this page
Add to favorites
Email this article to others
Authors
Articles by YU Weiting
Articles by ZHANG Demeng
Articles by LIU Xiudong
Articles by WANG Yunhong
Articles by TONG Jun
Articles by ZHANG Mengxue
Articles by MA Xiaojun
References:
Boontheekul T, Kong H J, Mooney D J. 2005. Controlling alginate gel degradation utilizing partial oxidation and bimodal molecular weight distribution. Biomaterials, 26(15):2 455-2 465, https://doi.org/10.1016/j.biomaterials. 2004.06.044.
Ching S H, Bansal N, Bhandari B. 2017. Alginate gel particles-a review of production techniques and physical properties. Critical Reviews in Food Science and Nutrition, 57(6):1 133-1 152, https://doi.org/10.1080/104 08398.2014.965773.
Desai S, Perkins J, Harrison B S, Sankar J. 2010.Understanding release kinetics of biopolymer drug delivery microcapsules for biomedical applications. Materials Science and Engineering:B, 168(1-3):127-131, https://doi.org/10.1016/j.mseb.2009.11.006.
Du A W, Stenzel M H. 2014. Drug carriers for the delivery of therapeutic peptides. Biomacromolecules, 15(4):1 097-1 114, https://doi.org/10.1021/bm500169p.
Fang Y H, Xiao C M, Wu H, Lin S B. 2005. Graft copolymerization of vinyl acetate onto calcium alginate aquagel. Journal of Huaqiao University (Natural Science), 26(2):138-140. (in Chinese with English abstract)
Lee K Y, Mooney D J. 2012. Alginate:properties and biomedical applications. Progress in Polymer Science, 37(1):106-126, https://doi.org/10.1016/j.progpolymsci.2011.06.003.
Liakos I, Rizzello L, Bayer I S, Pompa P P, Cingolani R, Athanassiou A. 2013. Controlled antiseptic release by alginate polymer films and beads. Carbohydrate Polymers, 92(1):176-183, https://doi.org/10.1016/j.carbpol.2012.09.034.
Liu X D, Yu W T, Wang W, Xiong Y, Ma X J, Yuan Q. 2008.Polyelectrolyte microcapsules prepared by alginate and chitosan for biomedical application. Progress in Chemistry, 20(1):126-139. (in Chinese with English abstract)
Lopes M, Abrahim B, Veiga F, Seiça R, Cabral L M, Arnaud P, Andrade J C, Ribeiro A J. 2017. Preparation methods and applications behind alginate-based particles. Expert Opinion on Drug Delivery, 14(6):769-782, https://doi.org/10.1080/17425247.2016.1214564
Mei L, He F, Zhou R Q, Wu C D, Liang R, Xie R, Ju X J, Wang W, Chu L Y. 2014. Novel intestinal-targeted Ca-alginatebased carrier for pH-responsive protection and release of lactic acid bacteria. ACS Applied Materials & Interfaces, 6(8):5 962-5 970, https://doi.org/10.1021/am501011j.
Pawar S N, Edgar K J. 2012. Alginate derivatization:a review of chemistry, properties and applications. Biomaterials, 33(11):3 279-3 305, https://doi.org/10.1016/j.biomaterials. 2012.01.007.
Shin S H, Lee J, Lim K S, Rhim T, Lee S K, Kim Y H, Lee K Y. 2013. Sequential delivery of TAT-HSP27 and VEGF using microsphere/hydrogel hybrid systems for therapeutic angiogenesis. Journal of Controlled Release, 166(1):38-45, https://doi.org/10.1016/j.jconrel.2012.12.020.
Song H Y, Yu W T, Gao M, Liu X D, Ma X J. 2013.Microencapsulated probiotics using emulsification technique coupled with internal or external gelation process. Carbohydrate Polymers, 96(1):181-189, https://doi.org/10.1016/j.carbpol.2013.03.068.
Xu G Z, Liu X D, Wang B, Yu W T, Ding D H, Ma X J. 2013.Graft copolymerization of sodium alginate-vinyl acetate and performance evaluation. Chemical Research and Application, 25(8):1 097-1 101. (in Chinese with English abstract)
Xu Y L, Ni C H. 2012. Synthesis of amphiphilic block copolymer via graft polymerization of DAAM and SA.Applied Chemical Industry, 41(2):278-281. (in Chinese with English abstract)
Yang J S, Xie Y J, He W. 2011. Research progress on chemical modification of alginate:a review. Carbohydrate Polymers, 84(1):33-39, https://doi.org/10.1016/j.carbpol. 2010.11.048.
Yu W T, Lin J Z, Liu X D, Xie H G, Zhao W, Ma X J. 2010.Quantitative characterization of membrane formation process of alginate-chitosan microcapsules by GPC.Journal of Membrane Science, 346(2):296-301, https://doi.org/10.1016/j.memsci.2009.09.049.
Zhang X L, He H Y, Yen C, Ho W, Lee L J. 2008. A biodegradable, immunoprotective, dual nanoporous capsule for cell-based therapies. Biomaterials, 29(31):4 253-4 259, https://doi.org/10.1016/j.biomaterials.2008.07.032.
Zhang Y, Chan H F, Leong K W. 2013. Advanced materials and processing for drug delivery:the past and the future.Advanced Drug Delivery Reviews, 65(1):104-120, https://doi.org/10.1016/j.addr.2012.10.003.