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L� Fengyi, LI Xiaoming, CHI Luping, MENG Linghong, WANG Bingui. A new acyclic peroxide from Aspergillus nidulans SD-531, a fungus obtained from deep-sea sediment of cold spring in the South China Sea[J]. Journal of Oceanology and Limnology, 2020, 38(4): 1225-1232

A new acyclic peroxide from Aspergillus nidulans SD-531, a fungus obtained from deep-sea sediment of cold spring in the South China Sea

L� Fengyi1,2, LI Xiaoming1,3, CHI Luping1,2, MENG Linghong1,3, WANG Bingui1,3
1 Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, and Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, China;
2 College of Earth Science, University of Chinese Academy of Sciences, Beijing 100049, China;
3 Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao 266071, China
A new acyclic peroxide derivative asperoxide A (1), along with 13 known compounds, namely, microperfuranone (2), 9-hydroxymicroperfuranone (3), gibellulin A (4), lecanoric acid (5), terrequinone A (6), sterigmatocystin (7), isosecosterigmatocystin (8), arugosin C (9), curvularin (10), 3,3'-diindolylmethane (11), austinol (12), austin (13), and dehydroaustin (14), were isolated and identified from the culture extract of Aspergillus nidulans SD-531, a fungus obtained from the deep-sea sediment of cold spring in the South China Sea. Their structures were determined based on detailed interpretation of nuclear magnetic resonance (NMR) spectroscopic and mass spectrometry data analysis. All the isolated compounds were evaluated for antimicrobial activities against human and aquatic bacteria as well as plant pathogenic fungi. Compounds 1-8, 10, and 11 exhibited antimicrobial activities against some of the tested strains with minimum inhibitory concentration (MIC) values ranging from 2 to 64 μg/mL. Compounds 4 and 6 displayed strongest activities among the tested samples and might be used as promising molecules for the development of natural antimicrobial agents.
Key words:    acyclic peroxide|Aspergillus nidulans|cold spring fungus|antimicrobial activity   
Received: 2020-01-19   Revised: 2020-03-03
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